Malaria vaccine a letdown for infants

LONDON (AP) — An experimental malaria vaccine once thought promising is turning out to be a disappointment, with a new study showing it is only about 30 percent effective at protecting infants from the killer disease.

That is a significant drop from a study last year done in slightly older children, which suggested the vaccine cut the malaria risk by about half — though that is still far below the protection provided from most vaccines. According to details released on Friday, the three-shot regimen reduced malaria cases by about 30 percent in infants aged 6 to 12 weeks, the target age for immunization.

Dr. Jennifer Cohn, a medical coordinator at Doctors Without Borders, described the vaccine's protection levels as "unacceptably low." She was not linked to the study.

Scientists have been working for decades to develop a malaria vaccine, a complicated endeavor since the disease is caused by five different species of parasites. There has never been an effective vaccine against a parasite. Worldwide, there are several dozen malaria vaccine candidates being researched.

In 2006, a group of experts led by the World Health Organization said a malaria vaccine should cut the risk of severe disease and death by at least half and should last longer than one year. Malaria is spread by mosquitoes and kills more than 650,000 people every year, mostly young children and pregnant women in Africa. Without a vaccine, officials have focused on distributing insecticide-treated bed nets, spraying homes with pesticides and ensuring access to good medicines.

In the new study, scientists found babies who got three doses of the vaccine had about 30 percent fewer cases of malaria than those who didn't get immunized. The research included more than 6,500 infants in Africa. Experts also found the vaccine reduced the amount of severe malaria by about 26 percent, up to 14 months after the babies were immunized.

Scientists said they needed to analyze the data further to understand why the vaccine may be working differently in different regions. For example, babies born in areas with high levels of malaria might inherit some antibodies from their mothers which could interfere with any vaccination.

"Maybe we should be thinking of a first-generation vaccine that is targeted only for certain children," said Dr. Salim Abdulla of the Ifakara Health Institute in Tanzania, one of the study investigators.

Results were presented at a conference in South Africa on Friday and released online by the New England Journal of Medicine. The study is scheduled to continue until 2014 and is being paid for by GlaxoSmithKline and the PATH Malaria Vaccine Initiative.

"The results look bad now, but they will probably be worse later," said Adrian Hill of Oxford University, who is developing a competing malaria vaccine. He noted the study showed the Glaxo vaccine lost its potency after several months. Hill said the vaccine might be a hard sell, compared to other vaccines like those for meningitis and pneumococcal disease — which are both effective and cheap.

"If it turns out to have a clear 30 percent efficacy, it is probably not worth it to implement this in Africa on a large scale," said Genton Blaise, a malaria expert at the Swiss Tropical and Public Health Institute in Basel, who also sits on a WHO advisory board.

Eleanor Riley of the London School of Hygiene and Tropical Medicine, said the vaccine might be useful if used together with other strategies, like bed nets. She was involved in an earlier study of the vaccine and had hoped for better results. "We're all a bit frustrated that it has proven so hard to make a malaria vaccine," she said. "The question is how much money are the funders willing to keep throwing at it."

Glaxo first developed the vaccine in 1987 and has invested $300 million in it so far.

WHO said it couldn't comment on the incomplete results and would wait until the trial was finished before drawing any conclusions.

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Was Petraeus affair linked to lax Libya response?

CIA Director David Petraeus abruptly resigned Friday, citing an extramarital affair and the need to sort out the “personal and professional issues” involved.

The former commander of forces in Iraq and Afghanistan had built a stellar and nearly unassailable reputation – but mounting criticism of the Central Intelligence Agency’s response to the Benghazi, Libya, terrorist attack in September was beginning to tarnish that reputation.

Word of Mr. Petraeus’s resignation sent ripples of stunned surprise through both the intelligence and military communities, raising questions that revolved around how long the affair had been going on and how an officer known for his rigorous self-discipline – and attention to his reputation within the media — could have made such a lapse in judgment.

RECOMMENDED: 5 ways events overseas could shape Obama's second term

In a letter of resignation accepted by the White House, Petraeus said he had been married 37 years but had exercised “very poor judgment” in choosing to enter into an extramarital affair.

Petraeus, who was widely celebrated as a military commander and even occasionally mentioned as a potential presidential candidate, was sworn in as head of the CIA in September 2011 – and had kept a low profile since. Now speculation is sure to proliferate over whether that low profile resulted from Petraeus focusing on America’s intelligence gathering or on personal matters.

In particular, members of Congress and other officials demanding answers about the Benghazi attack on the US consulate that resulted in the deaths of four Americans – including the US ambassador to Libya, Christopher Stephens, and two CIA agents – will want to know if there was any link between Petraeus’s extramarital activities and what has been increasingly criticized as the CIA’s weak performance on the night of the Benghazi attack.

More broadly, the reason for Petraeus’s departure will raise questions about any compromising of US covert operations and intelligence. The potential for blackmail of intelligence officers is always a concern about the spy corps, but the involvement of the nation’s top spy in an extramarital affair takes the concern to a new level.

The Federal Bureau of Investigation has been probing Petraeus and the potential security risks posed by his affair, CNN reported late Friday afternoon.

In the weeks since the Benghazi attack, officials have leaked information, including how Petraeus kept information on the CIA’s role in Benghazi so private that even Secretary of State Hillary Rodham Clinton was left to call Petraeus as the attack unfolded to try to get intelligence information from him.

Last week, CIA officials revealed that in fact, the intelligence agency’s operations in Benghazi dwarfed diplomatic operations at the consulate and that the CIA maintained what was described as an “annex,” about a mile from the diplomatic mission.

State Department officials have said there was an informal understanding that the annex and its agents would come to the assistance of the consulate (which had private contractors providing security) if a need arose. CIA officials insist their agents responded to the consulate’s distress calls within a half-hour.

In a statement released Friday afternoon, President Obama praised Petraeus for his “extraordinary service” to the country, adding, “By any measure, through his lifetime of service, David Petraeus has made our country safer and stronger.”

In a statement, Sen. John McCain (R) of Arizona highlighted Petraeus’s role in Iraq, saying that his “inspirational leadership and his genius were directly responsible – after years of failure – for the success of the surge in Iraq.”

But Petraeus’s success in Iraq and Afghanistan was a result to a certain extent of his focus on a counterinsurgency strategy that involved large numbers of troops fighting the enemy by incorporating nation-building into the battle. When Mr. Obama named Petraeus to head the CIA, it was widely interpreted as the president’s signal that he intended to wind down America’s wars and shift from a counterinsurgency strategy to counterterrorism.

Obama did not cite Petraeus’s reason for resigning but did say, “Going forward, my thoughts and prayers are with Dave and Holly Petraeus, who has done so much to help military families through her own work. I wish them the very best at this difficult time.”

Mrs. Petraeus is the assistant director of the Consumer Financial Protection Bureau, where she supports veterans and troops facing difficulties as a result of the financial crisis.

Obama initially tried to convince Petraeus not to resign, according to some souces. “I am told that President Obama tried to talk Petraeus out of resigning, but Petraeus took the samurai route and insisted that he had done a dishonorable thing and now had to try to balance it by doing the honorable thing and stepping down as CIA director,” Tom Ricks reports in his blog “The Best Defense.”

Such a move is in keeping with the military culture in which Petraeus rose to the rank of four-star general.

Under the Uniform Code of Military Justice, adultery is a punishable offense for soldiers if the conduct is shown to be detrimental “to good order and discipline in the armed forces or was of a nature to bring discredit upon the armed forces.”

Obama said that Michael Morell, deputy director of the CIA, would take over as acting director. Mr. Morell served briefly as acting director after Leon Panetta left the agency last year to become Defense secretary.

Petraeus was set to testify Thursday at a closed-door session of the Senate Intelligence Committee on the Benghazi attack, but it was unclear if his resignation would alter that schedule.

Sen. Dianne Feinstein (D) of California, the Intelligence Committee chair, told NBC News that Petraeus’s personal mistake should not have led to his resignation.

“I would have stood up for him,” she said. “I wanted him to continue. He was good, he loved the work, and he had a command of intelligence issues second to none.”

Obama, after winning reelection Tuesday, was already expected to make some changes in his national security team for a second term, but early speculation had been that Petraeus would stay on at the CIA. Now the job of spy chief will be added to the new-team mix.

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16 inmates killed in Sri Lanka prison shootout

COLOMBO, Sri Lanka (AP) — A shootout between rioting prisoners and security forces at a prison in Sri Lanka's capital killed at least 16 inmates, while police said Saturday that they arrested five prisoners who had managed to escape.

Another 42 people were wounded in the shootout Friday between inmates and army and police commandos that broke out after the rioting prisoners briefly took control of at least part of the facility in Colombo.

The prison was under control of security forces on Saturday, a senior prison official said. He spoke on condition of anonymity because he was not authorized to speak to the media.

Dr. Anil Jasinghe, director of the Colombo National Hospital, said 16 inmates had died in the clash and 23 others were injured and receiving treatment at the hospital.

Thirteen police officers, four soldiers, a prison guard and a passer-by also were being treated at the hospital for injuries, the doctor said.

Police spokesman Prishantha Jayakody said five prisoners who escaped from the prison had been arrested.

He said the fighting began when police commandos went to Welikada prison to conduct a search and were attacked by inmates hurling stones. He declined to provide more information. Officials often conduct raids for narcotics and communication devices.

An Associated Press photographer saw prisoners waving rifles atop the prison's roof Friday night.

Other prisoners piled into a three-wheeled vehicle and began driving toward a main city road before security forces outside the prison opened fire. The vehicle stopped, and three unmoving bodies could be seen.

Dozens of security officers then entered the prison, and volleys of gunfire rang out. Prisoners could be heard screaming, "Stop shooting!"

Army troops later were called in to help control the situation.

Prison chief P.W. Kodippili said inmates had broken into the prison's two armories and taken weapons stored there. The inmates opened fire at police commandos, who shot back, Kodippili told a local television channel Friday night.

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Associated Press photographer Gemunu Amarasinghe contributed to this report.

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Spotify to raise $100 million at $3 billion valuation – report

(Reuters) – Spotify is in the middle of a $ 100 million financing round that could value the music streaming company at just over $ 3 billion, the Wall Street Journal reported citing sources.

The Journal said Spotify would raise the fresh capital from multiple investors including Goldman Sachs. The WSJ report did not name any other investors.

Spotify has raised capital from outside investors several times since it set up shop in 2006, and was earlier reported to have been looking to secure a capital boost of about $ 200 million, at a valuation of about $ 4 billion.

Kleiner Perkins Caufield & Byers, Accel Partners and others have invested about $ 189 million in the company in its prior financing rounds.

The company has over 15 million active users and 4 million paying subscribers, for its on-demand service, which offers unlimited music streaming of some 18 million tracks.

(Reporting by Himank Sharma in Bangalore)

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Madonna fan guilty in NYC resisting arrest trial

NEW YORK (AP) — A former firefighter with a crush on Madonna has been convicted of resisting arrest outside her former New York City apartment building as he spray-painted poster boards with love notes.

A jury delivered its verdict Friday in Robert Linhart's trial. He could face up to a year in jail.

Defense lawyer Lawrence LaBrew tells the New York Post (http://bit.ly/ZgI4jl) that Linhart will appeal.

Linhart was arrested in September 2010. Police say he parked his SUV outside the singer's Manhattan apartment, laid out a tarp and wrote out such messages as "Madonna, I need you."

Jurors told the Post they felt it was fine for Linhart to express himself to the Material Girl. But they said they believed police testimony that he resisted arrest by flailing his arms.

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Calif. city plans to provide transgender surgeries

SAN FRANCISCO (AP) — San Francisco is preparing to become the first U.S. city to provide and cover the cost of sex reassignment surgeries for uninsured transgender residents.

The city's Health Commission voted Tuesday to create a comprehensive program for treating transgender people experiencing mental distress because of the mismatch between their bodies and their gender identities. San Francisco already provides transgender residents with hormones, counseling and routine health services, but has stopped short of offering surgical interventions, Public Health Director Barbara Garcia said Thursday after the vote was announced.

The idea for a new program that included surgeries came out of conversations between public health officials and transgender rights advocates who wanted mastectomies, genital reconstructions and other surgeries that are recommended for some transgender people covered under San Francisco's 5-year-old universal health care plan.

At the urging of the San Francisco Board of Supervisors and the San Francisco-based Transgender Law Center, the commission agreed this week to drop sex reassignment surgery from the list of procedures specifically excluded from the Healthy San Francisco plan.

But Garcia described the move as "a symbolic process" for now because the city currently does not have the expertise, capacity or protocols in place to provide the surgeries through its clinics and public hospital.

"The community felt the exclusion on Healthy San Francisco was discriminatory and we wanted to change that as the first step," she said.

Instead of expanding the existing plan, the Health Commission approved the establishment of a separate program that covers all aspects of transgender health, including gender transition. Garcia hopes to have it running by late next year, but said her department first needs to study how many people it would serve, how much it would cost, who would perform the surgeries and where they would be performed.

"Sex reassignment surgery is not the end all. It's one service that some transgender people want and some don't," she said. "We can probably manage this over the next three years without much of a budget increase because we already have these (other) services covered."

San Francisco in 2001 became the first city in the country to cover sex reassignment surgeries for government employees. Last year, Portland, Ore. did the same. The number of major U.S. companies covering the cost of gender reassignment surgery for transgender workers also doubled last year, reflecting a decades-long push by transgender activists to get insurance companies to treat such surgeries as medically necessary instead of elective procedures.

Kathryn Steuerman, a member of a transgender health advocacy group in San Francisco, said the city's latest move would help residents avoid going into debt to finance operations related to gender transition, as she did.

"I am filled with hope and gratitude that we are achieving this level of support for the well-being of the transgender community," Steuerman said.

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Obama breaks down while speaking to staff, volunteers

The morning after he won re-election, an emotional President Barack Obama credited his youthful staff of several hundred with running a campaign that will "go on in the annals of history."

"What you guys have accomplished will go on in the annals of history and they will read about it and they'll marvel about it," said Obama told his team Wednesday morning inside the Chicago campaign headquarters, tears streaming down his face.

"The most important thing you need to know is that your journey's just beginning. You're just starting. And whatever good we do over the next four years will pale in comparison to whatever you guys end up accomplishing in the years and years to come," he said.

The moment, captured by the Obama campaign's cameras and posted online, offers a rare glimpse at the president unplugged and emotional. During the first four years of his presidency, Obama has never been seen publicly crying.

He first came to Chicago, he told the campaign staff, "knowing that somehow I wanted to make sure that my life attached itself to helping kids get a great education or helping people living in poverty to get decent jobs and be able to work and have dignity. And to make sure that people didn't have to go to the emergency room to get health care."

"The work that I did in those communities changed me much more than I changed those communities because it taught me the hopes and aspirations and the grit and resilience of ordinary people," he said, as senior strategist David Axelrod and campaign manager Jim Messina looked on. "And it taught me the fact that under the surface differences, we all have common hopes and we all have common dreams. And it taught me something about how I handle disappointment and what it meant to work hard on a common endeavor, and I grew up."

"So when I come here and I look at all of you, what comes to mind is, it's not that you guys remind me of myself, it's the fact that you are so much better than I was in so many ways. You're smarter, you're so better organized, you're more effective," he said.

Obama said he expected many of those who helped to re-elect him will assume new roles in progressive politics, calling that prospect a "source of my strength and inspiration."

Senior campaign officials said Thursday that the Obama campaign infrastructure - the field offices and network of hundreds of thousands of volunteers - would undergo a period of transition in the coming weeks to determine how to remain sustainable and influential.

"We have remarkable staff, and the campaign that Jim [Messina] put together, you know, is the best in history," said senior Obama adviser David Plouffe. "But the reason those people got involved was because they believed in Barack Obama. It was the relationship between them and our candidate."

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China opens power transfer by keeping it off-stage

BEIJING (AP) — China's ruling communists opened a pivotal congress to initiate a power handover by giving a nod to their revolutionary past and broadly promising cleaner government while keeping off-stage the main event — the bargaining over seats in the new leadership.

All the main players were arrayed on the stage in the Great Hall of the People: President Hu Jintao, his successor Xi Jinping and a collection of retired party insiders. A golden hammer and sickle, the Communist Party's symbol, hung on the back wall. Yet in a nearly two-hour opening ceremony Thursday, scant mention was made of the transition or that in a week Hu will step down as party chief in favor of Xi in what would be only the second orderly transfer of power in 63 years of communist rule.

The congress is writ small the state of Chinese politics today. It's a largely ceremonial gathering of 2,200-plus delegates who meet while the real deal-making is done behind-the-scenes by the true power-holders.

The centerpiece event of the opening of the weeklong congress — a 90-minute speech by Hu — served politics, allowing him to define his legacy after a decade in office, while marshaling his clout to install his allies in the collective leadership that Xi will head.

"An important thing for him is to make sure that there's no critical, no negative summary judgment of the past 10 years," said Ding Xueliang, a Chinese politics expert at Hong Kong University of Science and Technology. Still, Ding said, "90 percent of the effort is on putting your people in place."

The party's public silence on a leadership transition that everyone knows is taking place and that politically minded Chinese have been discussing has deepened a palpable sense of public unease. Many Chinese feel the country is at a turning point, in need of new ideas to handle a slowing economy, growing piles of debt and rising public demands for more accountable, transparent government, if not democracy.

In signs of the public disquiet, at least five ethnic Tibetans in western China set themselves on fire Wednesday or Thursday in protests against Chinese rule of Tibetan areas, according to overseas Tibet support groups and the Tibetan government-in-exile in India.

At dawn in Tiananmen Square, next to the congress venue, a woman in her 30s threw pieces of torn paper into the air and shouted "bandits and robbers!" — a curse often leveled at corrupt local officials. She was taken away by the security forces, which have smothered all of Beijing for the congress.

In his speech, Hu cited many of the challenges China faces — a rich-poor gap, environmentally ruinous growth and imbalanced development between prosperous cities and a struggling countryside. Yet he offered little fresh thinking to address them and said restoring a relatively high growth would be the best way to deal with public expectations.

Only on tackling rampant corruption did Hu sound the alarm. He called on party members to be ethical and rein in their family members whose often showy displays of wealth have stoked public anger.

"Nobody is above the law," Hu said to the applause of the 2,309 delegates and invited guests, with Xi and other party notables on the dais behind him. He later said, "If we fail to handle this issue well, it could prove fatal to the party, and even cause the collapse of the party and the fall of the state."

Always an occasion for divisive bargaining, the leadership transition has been made more fraught by scandals that have fueled already high public cynicism that Chinese leaders are more concerned with power and wealth than government.

In recent months, one top leader, Bo Xilai, has been purged after his wife murdered a British businessman; a top aide to Hu was sidelined after his son crashed a Ferrari he shouldn't have been able to afford and foreign media reported that relatives of Xi and outgoing Premier Wen Jiabao had traded on their proximity to power to amass vast fortunes.

Public image aside, the scandals have especially weakened Hu, on whose watch they occurred, in the power-broking over the next leadership. In recent decades, the leadership line-ups have sought to balance different factions within the party. Who has prevailed won't be apparent until next Thursday, a day after the congress, when the members of the Politburo Standing Committee appear before the media.

On stage with Hu appeared one of his nemeses, his predecessor Jiang Zemin, who has supported Xi and is angling to fill many of the seats in the leadership with his allies. Nearby, dressed in a Mao jacket, sat 95-year-old Song Ping, a veteran of the revolution and party insider who was Hu's earliest political mentor.

Hu drew the line on political reform, a catchphrase for everything from greater transparency to democracy, even though retired party members, media commentators and government think tanks have called it an urgent need.

Hu's signature policy — a grab-bag of ideas meant to promote more balanced growth and stronger party rule that goes under the clunky phrase "the Scientific Outlook on Development" — has already been adopted in the party constitution. Hu's report to the congress called it "a powerful theoretical weapon" to guide the party.

"Even though this congress is about rejuvenation, passing the power to the young, what we see is the opposite," said Willy Lam of Chinese University of Hong Kong.

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Associated Press writers Gillian Wong, Christopher Bodeen, Didi Tang and Louise Watt contributed to this report.

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Exclusive: Google Ventures beefs up fund size to $300 million a year

SAN FRANCISCO (Reuters) - Google will increase the cash it allocates to its venture-capital arm to up to $300 million a year from $200 million, catapulting Google Ventures into the top echelon of corporate venture-capital funds.

Access to that sizeable checkbook means Google Ventures will be able to invest in more later-stage financing rounds, which tend to be in the tens of millions of dollars or more per investor.

It puts the firm on the same footing as more established corporate venture funds such as Intel's Intel Capital, which typically invests $300-$500 million a year.

"It puts a lot more wood behind the arrow if we need it," said Bill Maris, managing partner of Google Ventures.

Part of the rationale behind the increase is that Google Ventures is a relatively young firm, founded in 2009. Some of the companies it backed two or three years ago are now at later stages, potentially requiring larger cash infusions to grow further.

Google Ventures has taken an eclectic approach, investing in a broad spectrum of companies ranging from medicine to clean power to coupon companies.

Every year, it typically funds 40-50 "seed-stage" deals where it invests $250,000 or less in a company, and perhaps around 15 deals where it invests up to $10 million, Maris said. It aims to complete one or two deals annually in the $20-$50 million range, Maris said.

LACKING SUPERSTARS

Some of its investments include Nest, a smart-thermostat company; Foundation Medicine, which applies genomic analysis to cancer care; Relay Rides, a carsharing service; and smart-grid company Silver Spring Networks. Last year, its portfolio company HomeAway raised $216 million in an initial public offering.

Still, Google Ventures lacks superstar companies such as microblogging service Twitter or online bulletin-board company Pinterest. The firm's recent hiring of high-profile entrepreneur Kevin Rose as a partner could help attract higher-profile deals.

Soon it could have even more cash to play around with. "Larry has repeatedly asked me: 'What do you think you could do with a billion a year?'" said Maris, referring to Google chief executive Larry Page.

(Editing by Muralikumar Anantharaman)

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Mark Wahlberg to star in next 'Transformers' movie

LOS ANGELES (AP) — Mark Wahlberg, roll out.

"Transformers" director Michael Bay says the 41-year-old actor will star in the franchise's fourth film.

Bay called Wahlberg the "perfect guy to re-invigorate the franchise and carry on the Transformers' legacy" in a post on his blog Thursday. He previously squashed rumors that Wahlberg was joining the film franchise about warring robots.

Bay worked with Wahlberg on his upcoming film, "Pain and Gain."

"Transformers 4" is scheduled to be released by Paramount Pictures on June 27, 2014.

Bay has said the next film will take a new direction in the series. The first three movies starred Shia LaBeouf and featured Peter Cullen as the voice of Autobot general Optimus Prime.

The third "Transformers" film, "Dark of the Moon," was the second highest-grossing film of 2011.

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