EU drug regulator OKs Novartis' meningitis B shot

LONDON (AP) — Europe's top drug regulator has recommended approval for the first vaccine against meningitis B, made by Novartis AG.

There are five types of bacterial meningitis. While vaccines exist to protect against the other four, none has previously been licensed for type B meningitis. In Europe, type B is the most common, causing 3,000 to 5,000 cases every year.

Meningitis mainly affects infants and children. It kills about 8 percent of patients and leaves others with lifelong consequences such as brain damage.

In a statement on Friday, Andrin Oswald of Novartis said he is "proud of the major advance" the company has made in developing its vaccine Bexsero. It is aimed at children over two months of age, and Novartis is hoping countries will include the shot among the routine ones for childhood diseases such as measles.

Novartis said the immunization has had side effects such as fever and redness at the injection site.

Recommendations from the European Medicines Agency are usually adopted by the European Commission. Novartis also is seeking to test the vaccine in the U.S.

Read More..

Israel bombards Gaza Strip, shoots down rocket

GAZA CITY, Gaza Strip (AP) — Israel destroyed the headquarters of Hamas' prime minister and blasted a sprawling network of smuggling tunnels in the southern Gaza Strip on Saturday, broadening a blistering four-day-old offensive against the Islamic militant group even as diplomatic efforts to broker a cease-fire appeared to be gaining steam.

Hamas officials said a building used by Hamas for broadcasts was bombed and three people were injured. The injured were from Al Quds TV, a Lebanon-based television channel. The building is also used by foreign news outlets including Germany's ARD, Kuwait TV and the Italian RAI and others.

The Israeli military spokesman was not immediately aware of the strikes but said they were investigating.

In neighboring Egypt, President Mohammed Morsi hosted leaders from Hamas and two key allies, Qatar and Turkey, to seek a way to end the fighting.

"There are discussions about the ways to bring a cease-fire soon, but there are no guarantees until now," Morsi said at a news conference. He said he was working with Turkey, Arab countries, the U.S., Russia and western European countries to halt the fighting.

Israel launched the operation on Wednesday in what it said was an effort to end months of rocket fire out of the Hamas-ruled territory. It began the offensive with an unexpected airstrike that killed Hamas' powerful military chief, and since then has relentlessly targeted suspected rocket launchers and storage sites.

In all, 48 Palestinians, including 15 civilians, have been killed and more than 400 civilians wounded, according to medical officials.

Three Israeli civilians have been killed and more than 50 wounded.

Israeli military officials expressed satisfaction with their progress Saturday, claiming they have inflicted heavy damage to Hamas.

"Most of their capabilities have been destroyed," Maj. Gen. Tal Russo, Israel's southern commander, told reporters. Asked whether Israel is ready to send ground troops into Gaza, he said: "Absolutely."

"Most of their weapons are stored in civilian's homes, they launch rockets from residential areas. We do not want to hit civilians in Gaza but we do want to hit the hornets' nest of terror in Gaza," he said.

Footage released Saturday by the Islamic Jihad showed rockets being fired from a hidden bunker in a built-up area. It wasn't clear whether it was a residential neighborhood.

Israel's Deputy Foreign Minister Danny Ayalon told channel 1 TV that "Hamas is committing a double war crime, they are firing rockets at Israeli civilians while using Palestinian civilians as human shields."

The White House said President Barack Obama was also in touch with the Egyptian and Turkish leaders. The U.S. has solidly backed Israel so far.

Speaking on Air Force One, deputy national security adviser Ben Rhodes said that the White House believes Israel "has the right to defend itself" against attack and that the Israelis will make their own decisions about their "military tactics and operations."

Despite the bruising offensive, Israel has failed to slow the barrages of rockets from Gaza.

The Israeli military said 160 rockets were launched into Israel on Saturday, raising the total number to roughly 500 since this week's fighting began. Eight Israelis, including five civilians, were lightly wounded Saturday, the army said.

Israel carried out at least 300 airstrikes on Saturday, the military said, and it broadened its array of targets. One air raid flattened the three-story office building used by Hamas' prime minister, Ismail Haniyeh. He was not inside the building at the time.

In southern Gaza, aircraft went after the tunnels that militants use to smuggle in weapons and other contraband from neighboring Egypt. Tunnel operators said the intensity of the bombing was unprecedented, and that massive explosions could be heard kilometers (miles) away, both in Gaza and in Egypt.

The operators, speaking on condition of anonymity because of the illicit nature of their business, said they cannot approach the tunnel area to assess the damage, but the blasts appeared to be more powerful than in Israel's last major push to destroy the tunnels during a previous offensive four years ago. The tunnels are a key lifeline for Hamas, bringing in both weapons and supporting a lucrative trade that helps fund the group's activities.

Missiles also smashed into two small security facilities and the massive Hamas police headquarters in Gaza City, setting off a huge blaze that engulfed nearby houses and civilian cars parked outside, the Interior Ministry reported. No one was inside the buildings.

Early on Sunday, Gaza health official Ashraf al-Kidra said two teenagers were killed and ten people were injured when a building was hit.

Gaza residents reported heavy Israeli raids overnight.

Air attacks knocked out five electricity transformers, cutting off power to more than 400,000 people in southern Gaza, according to the Gaza electricity distribution company. People switched on backup generators for limited electrical supplies.

Hamas has unveiled an arsenal of more powerful, longer-range rockets this week, and for the first time has struck at Israel's two largest cities, Jerusalem and Tel Aviv. Both cities, more than 70 kilometers (45 miles) from Gaza, had previously been beyond rocket range.

In a psychological boost for Israel, a new rocket-defense system known as "Iron Dome" knocked down a rocket headed toward Tel Aviv, eliciting cheers from relieved residents huddled in fear after air raid sirens sounded in the city.

Associated Press video showed a plume of smoke following an intercepting missile out of a rocket-defense battery deployed near the city, followed by a burst of light overhead as it struck its target.

Police said a second rocket also targeted Tel Aviv. It was not clear where it landed or whether it was shot down. No injuries were reported. It was the third straight day the city was targeted.

Israel says the Iron Dome system has shot down some 250 of 500 rockets fired toward the country this week, most in southern Israel near Gaza.

Saturday's interception was the first time Iron Dome has been deployed in Tel Aviv. The battery was a new upgraded version that was only activated on Saturday, two months ahead of schedule, the Defense Ministry said.

Israel has vowed to stage a ground invasion, a scenario that would bring the scale of fighting closer to that of a war four years ago. Hamas was badly bruised during that conflict but has since restocked its arsenal with more and better weapons. Five years after seizing control of Gaza, it has also come under pressure from smaller, more militant groups to prove its commitment to fighting Israel as it turns its focus to governing the seaside strip.

Israel's Defense Minister Ehud Barak has authorized the emergency call-up of up to 75,000 reserve troops ahead of a possible ground offensive. Israel has massed thousands of troops and dozens of tanks and armored vehicles along the border in recent days.

Egypt, which is led by Hamas' parent movement, the Muslim Brotherhood, has been spearheading efforts to forge a cease-fire. Morsi has vowed to stand strong with the people of Gaza and this week recalled Cairo's ambassador from Israel to protest the offensive.

Quietly, though, non-Muslim Brotherhood members in Morsi's government are said to be pushing Hamas to end its rocket fire on Israel. Morsi is under pressure not to go too far and risk straining ties with Israel's ally, the United States.

The Hamas website said Saturday that its leader, Khaled Meshaal, met with the head of Egyptian intelligence for two hours Saturday in Cairo, a day after the Egyptian official was in the Gaza Strip trying to work out an end to the escalation in violence.

Hamas has not immediately accepted Egypt's proposal for a cease-fire, but the group's website said it could end its rocket fire if Israel agrees to end "all acts of aggression and assassination" and lift its five-year blockade on Gaza. Egypt will present the Hamas position to Israeli officials.

Israeli officials say they are not interested in a "timeout," and want firm guarantees that the rocket fire, which has paralyzed life in an area home to 1 million Israelis, finally ends. Past cease-fires have been short lived.

Israeli Prime Minister Benjamin Netanyahu said he spoke with the leaders of Britain, Poland, Portugal, Bulgaria to press his case. "No government in the world would allow a situation where its population lives under the constant threat of rockets," Netanyahu told them, according to a statement from his office.

The diplomatic activity in Cairo illustrated Hamas' rising influence in a changing Middle East. The Arab Spring has brought Islamists to power and influence across the region, helping Hamas emerge from years of isolation.

Morsi warned that a ground operation by Irael will have "repercussions" across the region. "All must realize the situation is different than before, and the people of the region now are different than before and the leaders are different than before," he said at a joint press conference with Turkey's Islamist prime minister, Recep Tayyip Erdogan. Erdogan, like Morsi, leads an Islamist government that has chilly diplomatic ties with Israel.

On Friday, Morsi sent his prime minister to Gaza on a solidarity mission with Hamas. And on Saturday, Tunisia's Foreign Minister Rafik Abdessalem visited Gaza as well.

___

Joe Federman reported from Jerusalem. Associated Press writers Karin Laub in Gaza City and Aya Batrawy in Cairo contributed reporting.

Read More..

Personal, strategic motivations for Obama in Asia

BANGKOK (AP) — For President Barack Obama, expanding U.S. influence in Asia is more than just countering China or opening up new markets to American businesses. It's also about building his legacy.

Fresh off re-election, Obama will make a significant investment in that effort during a quick run through Southeast Asia that begins Sunday. In addition to stops in Thailand and Cambodia, the president will make a historic visit to Myanmar, where his administration has led efforts to ease the once pariah nation out of international isolation.

The trip marks Obama's fourth visit to Asia in as many years. He kicks off his schedule in Bangkok. With a second term now guaranteed, aides say Obama will be a regular visitor to the region over the next four years as well.

"Continuing to fill in our pivot to Asia will be a critical part of the president's second term and ultimately his foreign policy legacy," said Ben Rhodes, Obama's deputy national security adviser.

The president's motivations in Asia are both personal and strategic.

Obama, who was born in Hawaii and lived in Indonesia as a child, has called himself America's first "Pacific president." The region gives him an opportunity to open up new markets for U.S. companies, promote democracy and ease fears of China's rise by boosting U.S. military presence in area.

The president, like many of his predecessors, had hoped to cement his foreign policy legacy in the Middle East. He visited two major allies in the region, Egypt and Saudi Arabia, on one of his first overseas trips as president and attempted to revive peace talks between Israel and the Palestinians.

But those talks stalled, and fresh outbursts of violence between Israel and the Palestinians make the prospects of a peace accord appear increasingly slim. The Obama-backed Arab Spring democracy push has had mixed results so far, with Islamists taking power in Egypt and progress in Libya tainted by the deadly attacks on the U.S. Consulate in Benghazi. Obama hasn't been back to the region since 2009.

In Asia, however, Obama will be viewed as something of an elder statesman when he returns less than two weeks after winning re-election. The region is undergoing significant leadership changes, most notably in China, where the Communist Party tapped new leaders last week. Japan and South Korea will both hold new elections soon.

"Most of the leaders he'll meet with will not have a tenure as long as he will as president," said Michael Green, an Asia scholar at the Washington-based Center for Strategic and International Studies. "So he'll go into this in a very strong position."

The centerpiece of Obama's whirlwind Asia tour is his visit to Myanmar. It will be the first time a U.S. president has visited the former pariah state.

Myanmar has become something of a pet project for Obama and his national security aides, who have cheered the country's significant strides toward democracy. Obama lifted some U.S. penalties on Myanmar, appointed a permanent U.S. ambassador and hosted democracy leader Aung San Suu Kyi at the White House this year.

Many of the same strategic motivations behind Obama's larger focus on Asia are at play in Myanmar, which is known by the U.S. as Burma.

The country long has oriented itself toward China, but the easing of sanctions gives American businesses a chance to gain a foothold there. It's also an opportunity for the Obama administration to show other nations in the region, and elsewhere in the world, that there are benefits to aligning with the U.S.

Still, there's little denying that history has been a draw for Obama's team when it comes to its dealings with Myanmar. That's led to criticism from some human rights groups that say Obama's visit is premature given that the country continues to hold political prisoners and has been unable to stem some ethnic violence.

"This trip risks being an ill-timed presidential pat on the back for a regime that has looked the other way as violence rages, destroying villages and communities just in the last few weeks," said Suzanne Nossel, the U.S.-based director of Amnesty International.

But the White House believes that "if we want to promote human rights and promote American values, we intend to do so through engagement," Rhodes said Saturday as Obama flew to Asia.

He said it was important for Obama to convey the message about "the type of action we'd like to see locked in, in Burma as it relates to political reform, as it relates to economic reform, and national reconciliation."

Obama's other stops in the region also underscore the potential pitfalls of going all-in in Asia.

Thailand's 2006 coup, which led to the ouster of the prime minister, strained relations with the U.S. and raised questions in Washington about the stability of its longtime regional ally. Cambodia, where Obama's visit also marks the first by a U.S. president, has a dismal human rights record.

White House officials have emphasized that Obama is visiting Cambodia because it is hosting the East Asia Summit, an annual meeting the U.S. now attends. Aides say the president will voice his human rights concerns during his meeting with Hun Sen, Cambodia's long-serving prime minister.

Still, human rights groups fear Obama's visit will be seen within Cambodia as an affirmation of the prime minister and a sign to opposition groups that the U.S. stands with the government, not with them.

Secretary of State Hillary Rodham Clinton was also traveling to Thailand where she was going to join Obama. Clinton then was to fly to Myanmar with Obama on Air Force One. It will be the last joint trip for the president and his secretary of state, the once presidential rival who went on to become Obama's peripatetic chief diplomat. Clinton is planning on leaving the administration.

___

Follow Julie Pace at http://twitter.com/jpaceDC

Read More..

Lady Gaga tweets some racy images before concert

BUENOS AIRES, Argentina (AP) — Lady Gaga's tweets were getting a lot of attention ahead of her Buenos Aires concert Friday night.

The Grammy-winning entertainer has more than 30 million followers on Twitter and that's where she shared a link this week to a short video showing her doing a striptease and fooling around in a bathtub with two other women.

She told her followers that it's a "surprise for you, almost ready for you to TASTE."

Then, in between concerts in Brazil and Argentina, she posted a picture Thursday on her Twitter page showing her wallowing in her underwear and impossibly high heels on top of the remains of what appears to be a strawberry shortcake.

"The real CAKE isn't HAVING what you want, it's DOING what you want," she tweeted.

Lady Gaga wore decidedly unglamorous baggy jeans and a blouse outside her Buenos Aires hotel Thursday as three burly bodyguards kept her fans at bay. Another pre-concert media event where she was supposed to be given "guest of honor" status by the city government Friday afternoon was cancelled.

After Argentina, she is scheduled to perform in Santiago, Chile; Lima, Peru; and Asuncion, Paraguay, before taking her "Born This Way Ball" tour to Africa, Europe and North America.

Read More..

EU drug regulator OKs Novartis' meningitis B shot

LONDON (AP) — Europe's top drug regulator has recommended approval for the first vaccine against meningitis B, made by Novartis AG.

There are five types of bacterial meningitis. While vaccines exist to protect against the other four, none has previously been licensed for type B meningitis. In Europe, type B is the most common, causing 3,000 to 5,000 cases every year.

Meningitis mainly affects infants and children. It kills about 8 percent of patients and leaves others with lifelong consequences such as brain damage.

In a statement on Friday, Andrin Oswald of Novartis said he is "proud of the major advance" the company has made in developing its vaccine Bexsero. It is aimed at children over two months of age, and Novartis is hoping countries will include the shot among the routine ones for childhood diseases such as measles.

Novartis said the immunization has had side effects such as fever and redness at the injection site.

Recommendations from the European Medicines Agency are usually adopted by the European Commission. Novartis also is seeking to test the vaccine in the U.S.

Read More..

Head vs. heart: Egypt's Gaza dilemma

The hostilities threatening to escalate into all-out war between Israel and Palestinian militants in Gaza concern the two antagonists first and foremost, but the course the fighting takes is likely to be equally consequential for Egyptian President Mohammed Morsi – and for his relations with the United States.

Egypt’s Islamist president finds himself pulled in competing directions by the head and the heart. The fighting this week – the result of heavy Israeli retaliation for escalating rocket fire from Gaza into southern Israel – has the Islamist Mr. Morsi in a tight spot: caught between his co-religionists across the border in Gaza, on one side, and Washington, upon which a struggling Egypt relies for economic and military assistance, on the other.

For some Middle East analysts, this could be a moment for Morsi to emerge and establish himself as a leader to be reckoned with in the unstable and leaderless post-Awakening Arab world. But successfully maneuvering this moment will take time. And with Israeli soldiers amassing on Gaza’s border, the analysts add, it’s unclear whether Morsi will have the chance to even take the leadership test the situation presents.

IN PICTURES: Gaza: battleground and daily life under Hamas' rule

“Morsi is definitely between the proverbial rock and hard place, but if he can pull together the elements to convince Hamas to stop the rockets … and he can defuse this situation, then I think he can emerge as a leader in the region,” says Aaron David Miller, a Middle East scholar at the Woodrow Wilson International Center in Washington. “But he needs time and space to try to do it, and I’m not sure the Israelis are going to allow him that time.”

The sudden flare-up involving Gaza and its Islamist leaders is also testing US influence in a region where the Arab Awakening has deposed a number of autocratic leaders more disposed to upholding a US-led system of security and stability – including former Egyptian President Hosni Mubarak – in favor of Islamist-led governments.

Morsi hails from the Muslim Brotherhood, as does Hamas, the militant Palestinian organization that governs Gaza. The rockets crashing into southern Israel have been lobbed by a collection of militant Islamist groups operating in Gaza, including some aligned with Iran. But after the Israelis launched retaliatory air strikes, including a strike that killed the Hamas military leader, Ahmed Jabari, Hamas has continued the barrage of rocket fire into Israel and the fighting has largely boiled down to a battle between Israel and Hamas.

Morsi has made his sympathies clear on Egyptian television, lamenting the spilling of Palestinian blood and railing against what he calls the Israeli “aggression.” But privately he is apparently sounding more amenable to trying to convince Hamas to stand down, perhaps by accepting a cease-fire. Morsi has spoken by phone with President Obama and Secretary of State Hillary Rodham Clinton several times this week, US officials say.

This is where Morsi’s head comes in. Egypt depends on the US for some $1.5 billion in annual assistance, not to mention Washington’s advocacy before international financial institutions – including the International Monetary Fund, where Egypt currently has a $4.5 billion loan under consideration.

Egypt’s relations with the US have not sailed through the stormy waters of the Egyptian revolution unscathed. The uncertainty and growing mistrust that now characterize what was once the solid core of US relations with the region were captured by Obama’s comment in an interview in September: “I don’t think we would consider [Egypt] an ally,” the president said, “but we don’t consider them an enemy,” either.

The turbulence has led some analysts to wonder if Morsi might be willing to jeopardize US assistance in order to pursue pro-Islamist – and more overtly anti-Israeli – policies. This week’s deadly violence between Israel and Hamas has led to some speculation that Morsi, who recalled Egypt’s ambassador to Israel, might be willing to take steps jeopardizing the Camp David peace accords between Egypt and Israel.

But experts like Mr. Miller point out that Egypt’s economic stability is linked to Camp David, since receipt of the substantial US aid, and favorable treatment with international financial institutions, are both products of the 1979 accords.

Without a treaty, there’s no special relationship with the US – whether or not it’s as an ally.

Morsi might take a number of steps to convince Hamas to pull back. He could agree to open the Egypt-Gaza border (this possibility is why Israel is pressing Egypt to block any passage of weapons, including replacement rocket launch pads, across its border) and he could work with Saudi Arabia and other patron states to up their financial assistance to Gaza, Miller says.

Morsi might then come out of the Gaza crisis with a much shinier image – the question now may be whether Israel is willing to hold back to see if Egypt’s Islamist leader is capable of this role.

IN PICTURES: Gaza: battleground and daily life under Hamas' rule

Related stories

Read this story at csmonitor.com

Become a part of the Monitor community

Read More..

Myanmar to consider rights for Rohingya minority

YANGON, Myanmar (AP) — Myanmar's president has pledged to consider new rights for the stateless Rohingya minority ahead of a landmark visit by President Barack Obama, but stopped short of a full commitment that citizenship and other new freedoms would be granted.

In a letter sent to the United Nations on Friday, President Thein Sein made conciliatory remarks that condemned the "senseless violence" in western Rakhine state between Rakhine Buddhists and Muslim Rohingya.

Almost 200 people have died and more than 100,000 have been displaced since June in fighting between the two communities, an eruption of longstanding hatred that highlights the fragility of Myanmar's transition toward democracy.

Thein Sein made no promises in his letter and offered no timeline for resolving the tensions, but it marked an overture to the international community and to Obama, who arrives Monday for the first visit to Myanmar by a U.S. president.

The White House has urged Myanmar to take urgent action to end the strife and has said Obama will press the matter with Thein Sein, along with demands to free political prisoners as the Southeast Asian country transitions to democracy after a half-century of military rule.

In his letter, Thein Sein said his government was prepared to address contentious issues "ranging from resettlement of displaced populations to granting of citizenship," according to a statement from the spokesperson for U.N. Secretary-General Ban Ki-moon that contained excerpts from the letter.

Thein Sein said he also would look at issues including work permits and permits granting freedom of movement for the Rohingya to ensure they are treated in line with "accepted international norms."

The U.N. statement called Thein Sein's letter a step "in the right direction."

It was not clear from his letter whether Thein Sein was changing his stance on citizenship for the Rohingya. He has previously cited strict citizenship laws stating that only Rohingya whose families settled in the country before independence from Britain in 1948 were considered citizens.

The United Nations has called the Rohingya — who are widely reviled by the Buddhist majority in Myanmar — among the most persecuted people on Earth.

Myanmar denies the Rohingya citizenship, even though many of their families have lived in Myanmar for generations. The government considers them to be illegal migrants from Bangladesh, but Bangladesh also rejects them, rendering them stateless.

The U.N. estimates that 800,000 Rohingya live in Myanmar, where they face heavy-handed restrictions: They need permission to marry, have more than two children and travel outside of their villages.

___

Associated Press writer Jocelyn Gecker contributed to this report from Bangkok.

Read More..

News Summary: UK court overturns Facebook demotion

PUNISHED: Britain‘s High Court ruled Friday that a man had been unfairly stripped of a management position and demoted for saying in a Facebook post that he was opposed to gay marriage.

COURT RULING: The court said the Trafford Housing Trust breached Adrian Smith‘s contract and a judge added that Smith had not done anything wrong. Smith had written on Facebook that gay weddings in churches would be “an equality too far.”

EVOLVING LAW: In Britain, same-sex couples can form civil partnerships that carry the same legal rights marriages do. The government plans to introduce legislation allowing civil marriages as well.

Social Media News Headlines – Yahoo! News

Read More..

Lady Gaga tweets some racy images before concert

BUENOS AIRES, Argentina (AP) — Lady Gaga's tweets were getting a lot of attention ahead of her Buenos Aires concert Friday night.

The Grammy-winning entertainer has more than 30 million followers on Twitter and that's where she shared a link this week to a short video showing her doing a striptease and fooling around in a bathtub with two other women.

She told her followers that it's a "surprise for you, almost ready for you to TASTE."

Then, in between concerts in Brazil and Argentina, she posted a picture Thursday on her Twitter page showing her wallowing in her underwear and impossibly high heels on top of the remains of what appears to be a strawberry shortcake.

"The real CAKE isn't HAVING what you want, it's DOING what you want," she tweeted.

Lady Gaga wore decidedly unglamorous baggy jeans and a blouse outside her Buenos Aires hotel Thursday as three burly bodyguards kept her fans at bay. Another pre-concert media event where she was supposed to be given "guest of honor" status by the city government Friday afternoon was cancelled.

After Argentina, she is scheduled to perform in Santiago, Chile; Lima, Peru; and Asuncion, Paraguay, before taking her "Born This Way Ball" tour to Africa, Europe and North America.

Read More..

Diabetes rates rocket in Oklahoma, South

NEW YORK (AP) — The nation's diabetes problem is getting worse, and the biggest jump over 15 years was in Oklahoma, according to a new federal report issued Thursday.

The diabetes rate in Oklahoma more than tripled, and Kentucky, Georgia and Alabama also saw dramatic increases since 1995, the study showed.

The South's growing weight problem is the main explanation, said Linda Geiss, lead author of the report by the Centers for Disease Control and Prevention study.

"The rise in diabetes has really gone hand in hand with the rise in obesity," she said.

Bolstering the numbers is the fact that more people with diabetes are living longer because better treatments are available.

The disease exploded in the United States in the last 50 years, with the vast majority from obesity-related Type 2 diabetes. In 1958, fewer than 1 in 100 Americans had been diagnosed with diabetes. In 2010, it was about 1 in 14.

Most of the increase has happened since 1990.

Diabetes is a disease in which the body has trouble processing sugar; it's the nation's seventh leading cause of death. Complications include poor circulation, heart and kidney problems and nerve damage.

The new study is the CDC's first in more than a decade to look at how the nationwide boom has played out in different states.

It's based on telephone surveys of at least 1,000 adults in each state in 1995 and 2010. Participants were asked if a doctor had ever told them they have diabetes.

Not surprisingly, Mississippi — the state with the largest proportion of residents who are obese — has the highest diabetes rate. Nearly 12 percent of Mississippians say they have diabetes, compared to the national average of 7 percent.

But the most dramatic increases in diabetes occurred largely elsewhere in the South and in the Southwest, where rates tripled or more than doubled. Oklahoma's rate rose to about 10 percent, Kentucky went to more than 9 percent, Georgia to 10 percent and Alabama surpassed 11 percent.

An official with Oklahoma State Department of Health said the solution is healthier eating, more exercise and no smoking.

"And that's it in a nutshell," said Rita Reeves, diabetes prevention coordinator.

Several Northern states saw rates more than double, too, including Washington, Idaho, Montana, Wyoming, South Dakota, Minnesota, Missouri, Ohio and Maine.

The study was published in CDC's Morbidity and Mortality Weekly Report.

___

Associated Press writer Ken Miller in Oklahoma City contributed to this report.

___

Online:

CDC report: http://tinyurl.com/cdcdiabetesreport

Read More..

Signs mount of possible Israeli invasion of Gaza

JERUSALEM (AP) — Israeli aircraft targeted rocket launching operations of Gaza militants early Friday as troops, tanks and armored personnel carriers massed near the Palestinian territory, signaling a ground invasion might be growing near.

Fighting between the two sides escalated sharply Thursday with a first-ever militant attack on the Tel Aviv area, menacing Israel's heartland. No casualties were reported there, but three people died in the country's rocket-scarred south when a projectile slammed into an apartment building.

The death toll in the densely populated Palestinian territory climbed to 19, including five children, according to Palestinian health officials, as waves of Israeli fighter planes and drones sent missiles hurtling down on suspected weapons stores and rocket-launching sites.

Early Friday, 85 missiles exploded within 45 minutes in Gaza City, sending black pillars of smoke towering above the coastal strip's largest city. The military said it was targeting underground rocket launching sites.

One missile hit the Interior Ministry, a symbol of Hamas power, and another hit an empty house belonging to a senior Hamas commander. Those strikes, together with an attack on a generator building near the home of Gaza's Hamas prime minister, Ismail Haniyeh, signaled that Israel was expanding its offensive beyond military targets.

The fighting has already widened the instability gripping a region in the throes of war and regime upheavals. It has straining already frayed relations with Egypt, which was sending its prime minister to Gaza later Friday in a show of solidarity with its militant Hamas rulers.

Israel and Hamas had largely observed an informal truce since Israel's devastating incursion into Gaza four years ago, but rocket fire and Israeli airstrikes on militant operations didn't halt entirely. The latest flare-up exploded into major violence Wednesday when Israel assassinated Hamas' military chief, following up with a punishing air assault meant to cripple the militants' ability to terrorize Israel with rockets.

The Israeli military reported early Friday that its aircraft had struck more than 350 targets since the beginning of its operation against Hamas' rocket operations.

After nightfall Thursday, several explosions shook Gaza City several minutes apart, a sign the strikes were not letting up. The military said the targets were about 70 underground rocket-launching sites.

The Israeli offensive has not deterred the militants from striking back with more than 400 rockets aimed at southern Israel. For the first time, they also unleashed the most powerful weapons in their arsenal — Iranian-made Fajr-5 rockets capable of reaching Tel Aviv.

The two rockets that struck closest to Tel Aviv appear to have landed in the Mediterranean Sea, defense officials said, and another hit an open area on Tel Aviv's southern outskirts.

No injuries were reported, but the rocket fire — the first in the area from Gaza — sowed panic in Tel Aviv and made the prospect of a ground incursion more likely. The government later approved the mobilization of up to 30,000 reservists for a possible invasion.

Israeli Prime Minister Benjamin Netanyahu said the army was hitting Hamas hard with what he called surgical strikes, and warned of a "significant widening" of the Gaza operation. Israel will "continue to take whatever action is necessary to defend our people," said Netanyahu, who is up for re-election in January.

At least 12 trucks were seen transporting tanks and armored personnel carriers toward Gaza late Thursday, and buses carrying soldiers headed toward the border area. Israeli TV stations said a Gaza operation was expected on Friday, though military officials said no decision had been made.

"We will continue the attacks and we will increase the attacks, and I believe we will obtain our objectives," said Lt. Gen. Benny Gantz, Israel's military chief.

An Israeli ground offensive could be costly to both sides. In the last Gaza war, Israel devastated large areas of the territory, setting back Hamas' fighting capabilities but also paying the price of increasing diplomatic isolation because of a civilian death toll numbering in the hundreds.

The current round of fighting is reminiscent of the first days of that three-week offensive against Hamas. Israel also caught Hamas off guard then with a barrage of missile strikes and threatened to follow up with a ground offensive.

Much has changed since then.

Israel has improved its missile defense systems, but it is facing a more heavily armed Hamas. Israel estimates the militants have 12,000 rockets, including more sophisticated weapons from Iran and from Libyan stockpiles plundered after the fall of Moammar Gadhafi's regime there last year.

Also, regional alignments have changed dramatically since the last Gaza war. Hamas has emerged from its political isolation as its parent movement, the region-wide Muslim Brotherhood, has risen to power in several countries in the wake of last year's Arab uprisings, particularly in Egypt.

Egypt recalled its ambassador to protest the Israeli offensive and ordered its prime minister to lead a senior delegation to Gaza on Friday in a show of support for Hamas.

At the same time, while relations with Israel have cooled since the toppling of longtime Egyptian leader Hosni Mubarak, Islamist President Mohammed Morsi has not brought a radical change in Egypt's policy toward Israel. He has promised to abide by Egypt's 1979 peace deal with Israel and his government has continued contacts with Israel through its non-Brotherhood members.

___

Laub reported from Gaza City, Gaza Strip.

Read More..

Japan set for polls, no clear winner likely

TOKYO (AP) — Prime Minister Yoshihiko Noda was poised to dissolve Japan's parliament Friday, setting the stage for elections next month that will likely result in a weak coalition government with differing policies on how to fix the country's myriad problems.

Polls show that nearly half of the electorate is undecided on which party to support but it's clear that the ruling Democrats — in power for the last three years — are very likely to lose. Media reports say the elections will be held on Dec. 16.

Although the opposition Liberal Democratic Party, which led Japan for most of the post-World War II era, would win the most seats in the 480-seat lower house it will fall far short of a majority, according to the polls.

With no party a clear winner, Japan will end up with a coalition government made up of parties with differing policies and priorities. This could hinder decision-making as Japan wrestles with a two-decade economic slump, clean-up from last year's nuclear disaster, growing national debt and a rapidly aging population — not to mention a festering territorial dispute with China that is hurting business ties with its biggest trading partner.

"It's unlikely that the election will result in a clear mandate for anybody," said Koichi Nakano, a political science professor at Sophia University. "So in that sense, there's still going to be a lot of muddling through."

Japan must also decide whether it will follow through with plans to phase out nuclear power by 2040 — a move that many in the LDP oppose.

In a sudden turn of events, Noda abruptly said Wednesday in a one-on-one debate with LDP chief Shinzo Abe that he would dissolve parliament Friday if the opposition would agree to key reforms, including shrinking the size of parliament.

Abe, who said his party would go along with the measures, could get a second stab at being prime minister after his one-year stint in 2006-2007 if the LDP wins the most seats in the election. He would become Japan's seventh prime minister in seven years.

A staunch nationalist, Abe has taken a strong stance against China in the dispute over a cluster of uninhabited islands in the East China Sea controlled by Japan but also claimed by China and Taiwan. Abe suddenly quit as prime minister in 2007, citing health problems that he says are no longer an issue.

Noda's Democratic Party of Japan won a landslide victory in 2009 elections amid high hopes for change, ousting the conservative, business-friendly LDP, which had ruled Japan nearly continuously since 1955.

But those hopes have been dashed amid widespread disgust with the DPJ's failure to keep campaign promises and the government's handling of the Fukushima nuclear crisis triggered by the March 11, 2011, earthquake and tsunami.

Voters are also unhappy with Noda's centerpiece achievement during his nearly 15 months in office: passing legislation to double the nation's 5 percent sales tax by 2015 — a move he says is necessary to meet growing social security costs as the country grays.

Recent polls show about 25-30 percent of voters back the LDP, while support for the DPJ is in the low teens. With scattered support for a few other parties, that leaves nearly half of the public undecided, meaning the outcome is still quite unclear.

"I really don't know who to vote for," said 62-year-old taxi driver Tetsuo Suzuki. "I voted for the DPJ in the last election, but they couldn't seem to get things done. I don't really want to go back to the LDP, either."

"Japan doesn't seem as perky as it used to be," he said, ticking off the economy and territorial dispute with China as the two most pressing issues. "We want a strong leader who won't bend his principles."

Tapping into that voter dismay, outspoken leaders in the two biggest cities in Japan have decided to form their own national political parties, but they may not have enough time to get organized for the election.

The nationalistic governor of Tokyo, Shintaro Ishihara — who stirred up the flap with China by saying the Tokyo government would buy and develop the disputed islands called Senkaku by Japan and Diaoyu by China — resigned recently to create the Sunrise Party.

Toru Hashimoto, the brash, young mayor of Osaka, is working to draw up candidates for the newly formed Japan Restoration Party, although he said he himself will not run in the elections. Recent polls show his party has support in the 5 percent range.

The two men are reportedly in discussions to merge their parties and form a so-called "third force" to counter the LDP and DPJ, but it appears they are having difficulty reconciling some of their differing policy views, including on nuclear power.

Japan is going through a messy period of political transition with its merry-go-round of prime ministers and the emergence of various parties to challenge the long-dominant LDP, experts say.

"The era of one-party dominance is clearly over and behind us," said the professor, Nakano. "We know what we are transiting from, but we don't know where we are going."

Read More..

Juan Luis Guerra, Jesse & Joy win at Latin Grammys

LAS VEGAS (AP) — With their hit "Corre!" Mexican brother-sister pop duo Jesse & Joy ran away from the pack with four awards, including best song and best recording, at the 13th Annual Latin Grammys in Las Vegas on Thursday night.

Hosted by actors Cristian De La Fuente and Lucero, the ceremony attracted super-stars new and old, from across the world and from every Latin musical genre to the Mandalay Bay Events Center.

Just like at a big, multi-generational family party, new faces shared the spotlight with older generations, and traditional genres blended with electronica and hip-hop on stage.

Colombian rocker Juanes paired up with Carlos Santana, DJ trio and best new artist winner 3ball MTY threw down beats, and Pitbull rapped with dancers in gold spangled bikinis and hot pants.

Michel Telo, the Brazilian sertanejo or country music singer, performed with Las Vegas veterans Blue Man Group. Bachata heartthrob Prince Royce sang with veteran Mexican singer-songwriter Joan Sebastian.

Traditional Mexico met Las Vegas in a colorful number featuring Oaxaca native Lila Downs, Afro-Colombian singer Toto la Momposina and dancers in regional costumes.

Dominican musician Juan Luis Guerra, who came into the ceremony as the leading nominee with six bids, won producer of the year for Juanes' album "MTV Unplugged," which is also up for album of the year.

Guerra performed "En el Cielo No Hay Hospital," which brought the audience to its feet to dance, and for a standing ovation. He can only win four awards, since he is competing against himself in two categories.

Puerto Rican reggaeton singer Don Omar and Uruguayan alt rockers Cuarteto de Nos won two Latin Grammys each.

Oaxacan roots singer Lila Downs won best folkloric album for "Pecados y Milagros." Colombian singer Fonseca won for best tropical fusion album, and Los Tucanes de Tijuana won best norteno album for "365 Dias," the narco-corrido band's 32nd album.

Milly Quezada brought home best contemporary tropical album for "Aqui estoy yo."

"Long live merengue! Long live the Dominican Republic!" she said as she accepted the award.

If Colombian rocker Juanes wins in three of the four categories he's nominated in, he will become the most decorated Latin Grammy winner, breaking the record held by Puerto Rican rappers Calle 13.

Jazz trumpeter Arturo Sandoval brought three Latin Grammys for "Dear Diz (Every Day I Think of You)," but said it was just exciting as his first.

"The emotion is the same because one puts the same effort into each recording and the fact that the work is received well and respected by the public is a great satisfaction," he said.

The Latin Grammy celebration kicked off Wednesday by presenting its Person of the Year award to Caetano Veloso, one of the founders of the Tropicalismo movement.

The Brazilian singer, composer and activist was honored with performances by Juanes, Guerra, Nelly Furtado and Natalie Cole.

The event was broadcast live on Univision.

Read More..

Booze calories nearly equal soda's for US adults

NEW YORK (AP) — Americans get too many calories from soda. But what about alcohol? It turns out adults get almost as many empty calories from booze as from soft drinks, a government study found.

Soda and other sweetened drinks — the focus of obesity-fighting public health campaigns — are the source of about 6 percent of the calories adults consume, on average. Alcoholic beverages account for about 5 percent, the new study found.

"We've been focusing on sugar-sweetened beverages. This is something new," said Cynthia Ogden, one of the study's authors. She's an epidemiologist with the Centers for Disease Control and Prevention which released its findings Thursday.

The government researchers say the findings deserve attention because, like soda, alcohol contains few nutrients but plenty of calories.

The study is based on interviews with more than 11,000 U.S. adults from 2007 through 2010. Participants were asked extensive questions about what they ate and drank over the previous 24 hours.

The study found:

—On any given day, about one-third of men and one-fifth of women consumed calories from beer, wine or liquor.

—Averaged out to all adults, the average guy drinks 150 calories from alcohol each day, or the equivalent of a can of Budweiser.

—The average woman drinks about 50 calories, or roughly half a glass of wine.

—Men drink mostly beer. For women, there was no clear favorite among alcoholic beverages.

—There was no racial or ethnic difference in average calories consumed from alcoholic beverages. But there was an age difference, with younger adults putting more of it away.

For reference, a 12-ounce can of regular Coca-Cola has 140 calories, slightly less than a same-sized can of regular Bud. A 5-ounce glass of wine is around 100 calories.

In September, New York City approved an unprecedented measure cracking down on giant sodas, those bigger than 16 ounces, or half a liter. It will take effect in March and bans sales of drinks that large at restaurants, cafeterias and concession stands.

Should New York officials now start cracking down on tall-boy beers and monster margaritas?

There are no plans for that, city health department officials said, adding in a statement that while studies show that sugary drinks are "a key driver of the obesity epidemic," alcohol is not.

Health officials should think about enacting policies to limit alcoholic intake, but New York's focus on sodas is appropriate, said Margo Wootan, director of nutrition policy for the Center for Science in the Public Interest, a public health advocacy group.

Soda and sweetened beverages are the bigger problem, especially when it comes to kids — the No. 1 source of calories in the U.S. diet, she said.

"In New York City, it was smart to start with sugary drinks. Let's see how it goes and then think about next steps," she said.

However, she lamented that the Obama administration is planning to exempt alcoholic beverages from proposed federal regulations requiring calorie labeling on restaurant menus.

It could set up a confusing scenario in which, say, a raspberry iced tea may have a calorie count listed, while an alcohol-laden Long Island Iced Tea — with more than four times as many calories — doesn't. "It could give people the wrong idea," she said.

___

Online:

CDC report: http://www.cdc.gov/nchs/

Read More..

FBI terror expert started Petraeus probe

The FBI agent who investigated harassing emails to a Florida socialite, a probe that set off a chain of events leading to the resignation of CIA director David Petraeus over an extramarital affair, was a veteran investigator who has worked on high-profile terrorism cases.

The agent was identified as Frederick Humphries by a former federal agent, a source familiar with the Petraeus investigation and Humphries' attorney, Lawrence Berger.

Humphries, 47, received the initial complaint from Jill Kelley, 37, a Tampa, Fla., socialite, about "harassing" emails that an investigation traced back to Paula Broadwell, a 40-year-old author who co-wrote a biography of Petraeus, 60.

The investigation ultimately uncovered evidence of an affair between Broadwell and Petraeus, prompting Petraeus to resign last week.

Berger said his client's family "knew the Kelley family socially for several years." Jill Kelley asked Humphries for advice on what she perceived to be threatening e-mails and he "referred the matter to the bureau as appropriate."

Berger said his client has been wrongly characterized as a "whistleblower," but there is "no action pending against him, nor does he anticipate any future action."

Humphries "referred the matter to the FBI in accordance to proper protocol," Berger added, and the FBI investigation is taking its course.

AP Photo/Kevin P. Casey, AP Photo/Christopher Berkey, File

Classified Documents Taken from Alleged Petraeus Mistress' Home Watch Video

General John Allen's Relationship With Jill Kelley Watch Video

Gen. John Allen Scandal: Investigation of 'Inappropriate Relationship' Watch Video

Berger flatly declined to confirm or provide any details at all regarding Humphries' alleged contacts with the offices of either Rep. Dave Reichert, R-Wash., or House Majority Leader Rep. Eric Cantor, R-Va.

According to the New York Times, Humphries was allegedly concerned the case had been stalled for political reasons, and in late October contacted Reichert, whom he knew from his time working in Washington. The Times reported that Reichert put him in touch with Cantor, who then passed the message to FBI director, Robert Mueller.

An associate of Humphries told ABC News that it was hard to believe that Humphries had contacted elected officials about the case because "everyone knows that's professional suicide" and Humphries is "top notch."

Humphries has worked as a supervisor on Joint Terrorism Task Force in Tampa and has worked on high-profile terrorism cases.

In Seattle, Humphries worked the so-called Millenium terror plot in 1999, which prevented an Algerian al Qaeda member from bombing Los Angeles International Airport.

More recently, he testified in Florida in a terrorism case of Florida student Youssef Megahed and his associates.

In that case, back in 2007, a sheriff's deputy with the Berkeley County Sherriff's Office in South Carolina became suspicious when University of South Florida student Ahmed Mohamed and his companion, fellow USF student Megahed, did not initially stop when they were pulled over for speeding. The officer said he saw Megahed disconnect a power cord from a laptop computer as he approached the car. The deputy searched the vehicle. According to court records, he found safety fuses, several sections of cut PVC piping containing a potassium nitrate explosive mixture and containers filled with gasoline.

The pair was arrested that night for transporting explosives. Following the arrest, the FBI in Tampa and South Carolina began an investigation with the Joint Terrorism Task Force.

Read More..

Xi Jinping takes helm of China amid reform calls

BEIJING (AP) — Xi Jinping became China's new leader Thursday, assuming the top posts in the Communist Party and the powerful military in a political transition unbowed by scandals, a slower economy and public demands for reforms.

Xi was introduced as the new party general secretary at Beijing's Great Hall of the People a day after the close of a weeklong party congress that underlined the communists' determination to remain firmly in power. He and the six other men who will form China's new collective leadership, all dressed in dark suits, walked in line onto the red-carpeted stage.

Xi's appointment as chairman of the military commission, announced by the state Xinhua News Agency, marked a break from the recent tradition of retiring leaders holding onto the post for a transitional period to extend their influence. It meant outgoing leader Hu Jintao would relinquish all positions of power, giving Xi broader leeway to consolidate his authority.

The once-a-decade leadership change was carefully choreographed. It became clear Xi would lead China five years ago, when he was appointed to the Standing Committee — the nation's apex of power — as the highest-ranked member who would not be of retirement age this year.

Xi's colleagues in the new Standing Committee are Li Keqiang, the presumptive premier and chief economic official; Vice Premier Zhang Dejiang; Shanghai party secretary Yu Zhengsheng; propaganda chief Liu Yunshan; Vice Premier Wang Qishan; and Tianjin party secretary Zhang Gaoli.

In a speech broadcast live on Chinese state TV and worldwide, Xi said, "We shall do everything we can to live up to your trust and fulfill our mission."

"There are also many pressing problems within the party that need to be resolved, particularly corruption," Xi said. "We must make every effort to solve these problems. The whole party must stay on full alert."

The other six leaders were expressionless with their arms at their sides during Xi's 20-minute speech, then smiled to the audience when they walked off stage.

The son of a party elder, and vice president for the past five years, Xi will lead the world's No. 2 economy and newest diplomatic and military power amid increasingly vocal calls for economic and political reform — including from within the 82-million-member party itself.

At ease in front of people and with colleagues, Xi takes over the party leadership from the stiff, technocratic Hu, and is expected to assume the largely ceremonial presidency in March.

The ascent of Xi and Li, the premier-in-waiting, represents a generational change. Though they spent their youths laboring on farms, their university years and early careers took place when China was casting off the planned economy and turning to the free market and to the West. They are thought to be more open to new ideas than their predecessors, but nonetheless bound by China's consensus-oriented politics.

Thursday marked only the second tidy transition since communist rule was established in 1949, despite a turbulent political year that saw the downfall in a murder and corruption scandal of rising populist Bo Xilai, who had been seen as a key contender for the new leadership slate.

The outgoing Hu oversaw a decade of turgid economic growth and urban development and tried to make concern for ordinary people the hallmark of his tenure, but he also will be remembered for harshly stifling dissent and rolling back civil liberties.

At the same time, increased social freedoms have created a generation of Chinese who are more aware of their rights and more vocal about demanding them.

Read More..

Verizon says 1.4 million customers back on its fiber optic network

(Reuters) – Verizon Communications said fiber optic services have been restored to more than 1.4 million customers hurt by Hurricane Sandy.

The provider of telephone, Internet and television services said on November 1 that it may take another two weeks to restore telecommunication services for its customers after flooding and power outages knocked out services.

The company said it completed 364,000 repairs across the mid-Atlantic and northeast regions.

Verizon said it will provide credits for landline customers and fix equipment damaged due to the hurricane.

Verizon shares were up at $ 42.39 after the bell on Wednesday. They closed at $ 42.24 on the New York Stock Exchange.

(Reporting By Pallavi Ail in Bangalore; Editing by Maju Samuel)

Internet News Headlines – Yahoo! News

Read More..

Erdrich wins National Book Award for fiction

NEW YORK (AP) — The National Book Awards on Wednesday honored both longtime writers and new authors, from Louise Erdrich for "The Round House" to Katherine Boo for her debut work, "Beyond the Beautiful Forevers."

Erdrich, 58, has been a published and highly regarded author for nearly 30 years but had never won a National Book Award until being cited Wednesday for her story about an Ojibwe boy and his quest to avenge his mother's rape. A clearly delighted and surprised Erdrich, who's part Ojibwe, spoke in her tribal tongue and then switched to English as she dedicated her fiction award to "the grace and endurance of native people."

Boo's nonfiction book, set in a Mumbai slum, also is a story of a boy and his harsh and illuminating education in the consequences of crime or perceived crime. The author, a Pulitzer Prize-winning journalist currently on staff with The New Yorker, said she was grateful for the chance to live in a world she "didn't know" and for the chance to tell the stories of those otherwise ignored. She praised a fellow nominee and fellow Pulitzer-winning reporter, the late Anthony Shadid, for also believing in stories of those without fame or power.

Poetry winner David Ferry is a year older than one of the night's honorary recipients, Elmore Leonard. Ferry, 88, won for "Bewilderment: New Poems and Translations," a showcase for his versatile style. He fought back tears as he confided that he thought there was a chance for winning because he "was so much older" than the other nominees. He called the award a "pre-posthumous" honor.

The other competitive prize Wednesday went to William Alexander, whose "Goblin Secrets" won for young people's literature.

Alexander quoted fellow fantasy writer Ursula Le Guin in highlighting the importance of stories for shaping kids' imaginations and making the world a larger place than the one they live in.

"We have to remember that," Alexander said.

The ceremony went smoothly even though Superstorm Sandy badly damaged the offices of the award's organizer, the National Book Foundation, whose staffers had to work with limited telephone and mail access.

Winners, chosen by panels of fellow writers, each received $10,000. Judges looked through nearly 1,300 books.

Honorary prizes were given to Leonard and New York Times publisher and chairman Arthur O. Sulzberger Jr.

Read More..

Report: FDA wanted to close Mass pharmacy in 2003

WASHINGTON (AP) — Nearly a decade ago, federal health inspectors wanted to shut down the pharmacy linked to a recent deadly meningitis outbreak until it cleaned up its operations, according to congressional investigators.

About 440 people have been sickened by contaminated steroid shots distributed by New England Compounding Center, and more than 32 deaths have been reported since the outbreak began in September, according to the Centers for Disease Control and Prevention. That has put the Framingham, Mass.-based pharmacy at the center of congressional scrutiny and calls for greater regulation of compounding pharmacies, which make individualized medications for patients and have long operated in a legal gray area between state and federal laws.

The House Energy and Commerce Committee released a detailed history of NECC's regulatory troubles on Monday, ahead of a meeting Wednesday meeting to examine how the outbreak could have been prevented. The 25-page report summarizes and quotes from FDA and state inspection memos, though the committee declined to release the original documents.

The report shows that after several problematic incidents, Food and Drug Administration officials in 2003 suggested that the compounding pharmacy be "prohibited from manufacturing" until it improved its operations. But FDA regulators deferred to their counterparts in Massachusetts, who ultimately reached an agreement with the pharmacy to settle concerns about the quality of its prescription injections.

The congressional report also shows that in 2003 the FDA considered the company a pharmacy. That's significant because in recent weeks public health officials have charged that NECC was operating more as a manufacturer than a pharmacy, shipping thousands of doses of drugs to all 50 states instead of small batches of drugs to individual patients. Manufacturers are regulated by the FDA and are subject to stricter quality standards than pharmacies.

The report offers the most detailed account yet of the numerous regulatory complaints against the pharmacy, which nearly date back to its founding in 1998. Less than a year later, the company was cited by the state pharmacy board for providing doctors with blank prescription pads with NECC's information. Such promotional items are illegal in Massachusetts and the pharmacy's owner and director, Barry Cadden, received an informal reprimand, according to documents summarized by the committee.

Cadden was subject to several other complaints involving unprofessional conduct in coming years, but first came to the FDA's attention in 2002. Here are some key events from the report highlighting the company's early troubles with state and federal authorities:

__ In March of 2002 the FDA began investigating reports that five patients had become dizzy and short of breath after receiving NECC's compounded betamethasone repository injection, a steroid used to treat joint pain and arthritis that's different from the one linked to the current meningitis outbreak.

FDA inspectors visited NECC on April 9 and said Cadden was initially cooperative in turning over records about production of the drug. But during a second day of inspections, Cadden told officials "that he was no longer willing to provide us with any additional records," according to an FDA report cited by congressional investigators. The inspectors ultimately issued a report citing NECC for poor sterility and record-keeping practices but said that "this FDA investigation could not proceed to any definitive resolution," because of "problems/barriers that were encountered throughout the inspection."

__ In October of 2002, the FDA received new reports that two patients at a Rochester, N.Y., hospital came down with symptoms of bacterial meningitis after receiving a different NECC injection. The steroid, methylprednisolone acetate, is the same injectable linked to the current outbreak and is typically is used to treat back pain. Both patients were treated with antibiotics and eventually recovered, according to FDA documents cited by the committee.

When officials from the FDA and Massachusetts Board of Pharmacy visited NECC later in the month, Cadden said vials of the steroid returned by the hospital had tested negative for bacterial contamination. But when FDA scientists tested samples of the drug collected in New York they found bacterial contamination in four out of 14 vials sampled. It is not entirely clear whether FDA tested the same lot shipped to the Rochester hospital.

__ At a February 2003 meeting between state and federal officials, FDA staff emphasized "the potential for serious public consequences if NECC's compounding practices, in particular those relating to sterile products, are not improved." The agency issued a list of problems uncovered in its inspection to NECC, including a failure to verify if sterile drugs met safety standards.

But the agency decided to let Massachusetts officials take the lead in regulating the company, since pharmacies are typically regulated at the state level. It was decided that "the state would be in a better position to gain compliance or take regulatory action against NECC as necessary," according to a summary of the meeting quoted by investigators.

The FDA recommended the state subject NECC to a consent agreement, which would require the company to pass certain quality tests to continue operating. But congressional investigators say Massachusetts Board of Pharmacy did not take any action until "well over a year later."

__ In October 2004, the board sent a proposed consent agreement to Cadden, which would have included a formal reprimand and a three-year probationary period for the company's registration. The case ended without disciplinary action in 2006, when NECC agreed to a less severe consent decree with the state.

Massachusetts officials indicated Tuesday they are still investigating why NECC escaped the more severe penalty.

"I will not be satisfied until we know the full story behind this decision," the state's interim health commissioner Lauren Smith said in a transcript of her prepared testimony released a day ahead of delivery. Smith is one of several witnesses scheduled to testify Wednesday, including FDA Commissioner Margaret Hamburg.

The committee will also hear from the widow of 78-year-old Eddie C. Lovelace, a longtime circuit court judge in southern Kentucky. Autopsy results confirmed Lovelace received fungus-contaminated steroid injections that led to his death Sept. 17.

Joyce Lovelace will urge lawmakers to work together on legislation to stop future outbreaks caused by compounded drugs, according to a draft of her testimony.

"We now know that New England Compounding Pharmacy, Inc. killed Eddie. I have lost my soulmate and life's partner with whom I worked side by side, day after day for more than fifty years," Lovelace states.

Barry Cadden is also scheduled to appear at the hearing, after lawmakers issued a subpoena to compel him to attend.

The NECC has been closed since early last month, and Massachusetts officials have taken steps to permanently revoke its license. The pharmacy has recalled all the products it makes, including 17,700 single-dose vials of a steroid that tested positive for the fungus tied to the outbreak.

Read More..

Who's who in the Petraeus scandal

What started out as a leisurely stroll through the Philadelphia Museum of Art on Nov. 11 with his girlfriend, quickly turned into quite a surreal experience for Max Galuppo, 20, of Bloomsbury, N.J. Galuppo, a Temple University student, found his doppelganger in a 16th century...

Read More..

China's Communist Party conclave nearly finished

BEIJING (AP) — China's Communist Party was bringing its pivotal conclave to a close in largely choreographed steps Wednesday, a day before unveiling its leaders for the coming decade.

President Hu Jintao is expected to step down as party chief in favor of the anointed successor, Vice President Xi Jinping, in what would be only the second orderly transfer of power in 63 years of communist rule. The new leaders of the world's second-largest economy will face slowing growth, rising unrest among increasing assertive citizens and delicate relations with neighboring countries.

The party's 2,200-plus delegates filed into Beijing's Great Hall of the People in the morning to select members of the Central Committee, a panel of a few hundred people that approves leadership positions and sets broad policy goals, ahead of the scheduled close of the congress later Wednesday.

But the next lineup in China's apex of power, the Politburo Standing Committee, will be announced only on Thursday. Though congress and Central Committee delegates have some influence over leadership decisions, most of the lineup is decided among a core group of the most powerful party members and elders.

The congress votes are "fully democratic" but "there is a degree of inevitability," said party delegate Song Guofeng of Liaoning province as he entered the hall. "We need to have continuity in leadership to carry on. They are already in the leadership core. The stability of the party and of the county is important."

The voting concluded in the late morning, and the state Xinhua News Agency said in a brief report that Xi and premier-in-waiting Li Keqiang had been voted onto the Central Committee — an expected result.

Hu and senior leaders mostly in their late 60s are handing over power to Xi, 59, and colleagues of his generation over the next several months. Li, currently vice premier, already was tapped five years ago to be the country's next premier, China's top economic official. But other top positions were up for grabs.

China's leadership transitions are always occasions for fractious backroom bargaining, but this one has been further complicated by scandals that have fed public cynicism that their leaders are more concerned with power and wealth than government.

In recent months, Bo Xilai, a senior politician seen as a rising star, was purged after his aide exposed that his wife murdered a British businessman. An ally of Hu's was sidelined after his son died in the crash of a Ferrari he shouldn't have been able to afford. And foreign media recently reported that relatives of Xi and outgoing Premier Wen Jiabao had amassed vast wealth. The scandals have weakened Hu, on whose watch they occurred.

The congress is a largely ceremonial gathering of representatives — mostly carefully selected from the national and provincial political and military elite — who have met to endorse a work report delivered by Hu at the opening a week ago. The real deal-making for the top positions on the Standing Committee is done behind the scenes by the true power-holders.

Aside from appointing Central Committee members, delegates assembled inside the Great Hall of the People were tasked with selecting the membership of the party's internal corruption watchdog, the Central Discipline Inspection Committee, and with voting on amendments to the party's charter.

After the congress ends, the Central Committee meets Thursday to select the next Politburo and from that, the Politburo Standing Committee, largely on the advice of influential leaders.

The leaders also will select new members of the party's Central Military Commission, which oversees the 2.3 million-member People's Liberation Army. It is unclear if Hu will relinquish his position at the head of the commission or hold on to it for a period after retirement, as past leaders have, to retain influence.

Hu will remain president until March.

The next cohort of leaders face daunting challenges, including efforts to pull the country's economy into a recovery from a sharp downturn, tense territorial disputes with Japan and other neighbors and the demands of a new middle class and millions of rural migrants for a better life.

Read More..

Man who accused Elmo puppeteer of teen sex recants

NEW YORK (AP) — A man who accused Elmo puppeteer Kevin Clash of having sex with him when he was a teenage boy has recanted his story.

In a quick turnabout, the man on Tuesday described his sexual relationship with Clash as adult and consensual.

Clash responded with a statement of his own, saying he is "relieved that this painful allegation has been put to rest." He had no further comment.

The man, who has not identified himself, released his statement through the Harrisburg, Pa., law firm Andreozzi & Associates.

Sesame Workshop, which produces "Sesame Street" in New York, soon followed by saying, "We are happy that Kevin can move on from this unfortunate episode."

The whirlwind episode began Monday morning, when Sesame Workshop startled the world by announcing that Clash had taken a leave of absence from "Sesame Street" in the wake of allegations that he had had a relationship with a 16-year-old.

Clash, a 52-year-old divorced father of a grown daughter, swiftly denied the charges of his accuser, who is in his early 20s. In that statement Clash acknowledged that he is gay but said the relationship had been between two consenting adults.

Though it remained unclear where the relationship took place, sex with a person under 17 is a felony in New York if the perpetrator is at least 21.

Sesame Workshop, which said it was first contacted by the accuser in June, had launched an investigation that included meeting with the accuser twice and meeting with Clash. Its investigation found the charge of underage conduct to be unsubstantiated.

Clash said on Monday he would take a break from Sesame Workshop "to deal with this false and defamatory allegation."

Neither Clash nor Sesame Workshop indicated on Tuesday when he might return to the show, on which he has performed as Elmo since 1984.

Elmo had previously been a marginal character, but Clash, supplying the fuzzy red puppet with a high-pitched voice and a carefree, child-like personality, launched the character into major stardom. Elmo soon rivaled Big Bird as the face of "Sesame Street."

Though usually behind the scenes, Clash meanwhile achieved his own measure of fame. In 2006, he published an autobiography, "My Life as a Furry Red Monster," and he was the subject of the 2011 documentary "Being Elmo: A Puppeteer's Journey."

He has won 23 daytime Emmy awards and one prime-time Emmy.

___

Online:

http://www.sesamestreet.org

Read More..

British medical journal slams Roche on Tamiflu

LONDON (AP) — A leading British medical journal is asking the drug maker Roche to release all its data on Tamiflu, claiming there is no evidence the drug can actually stop the flu.

The drug has been stockpiled by dozens of governments worldwide in case of a global flu outbreak and was widely used during the 2009 swine flu pandemic.

On Monday, one of the researchers linked to the BMJ journal called for European governments to sue Roche.

"I suggest we boycott Roche's products until they publish missing Tamiflu data," wrote Peter Gotzsche, leader of the Nordic Cochrane Centre in Copenhagen. He said governments should take legal action against Roche to get the money back that was "needlessly" spent on stockpiling Tamiflu.

Last year, Tamiflu was included in a list of "essential medicines" by the World Health Organization, a list that often prompts governments or donor agencies to buy the drug.

Tamiflu is used to treat both seasonal flu and new flu viruses like bird flu or swine flu. WHO spokesman Gregory Hartl said the agency had enough proof to warrant its use for unusual influenza viruses, like bird flu.

"We do have substantive evidence it can stop or hinder progression to severe disease like pneumonia," he said.

In the U.S., the Centers for Disease Control and Prevention recommends Tamiflu as one of two medications for treating regular flu. The other is GlaxoSmithKline's Relenza. The CDC says such antivirals can shorten the duration of symptoms and reduce the risk of complications and hospitalization.

In 2009, the BMJ and researchers at the Nordic Cochrane Centre asked Roche to make all its Tamiflu data available. At the time, Cochrane Centre scientists were commissioned by Britain to evaluate flu drugs. They found no proof that Tamiflu reduced the number of complications in people with influenza.

"Despite a public promise to release (internal company reports) for each (Tamiflu) trial...Roche has stonewalled," BMJ editor Fiona Godlee wrote in an editorial last month.

In a statement, Roche said it had complied with all legal requirements on publishing data and provided Gotzsche and his colleagues with 3,200 pages of information to answer their questions.

"Roche has made full clinical study data ... available to national health authorities according to their various requirements, so they can conduct their own analyses," the company said.

Roche says it doesn't usually release patient-level data available due to legal or confidentiality constraints. It said it did not provide the requested data to the scientists because they refused to sign a confidentiality agreement.

Roche is also being investigated by the European Medicines Agency for not properly reporting side effects, including possible deaths, for 19 drugs including Tamiflu that were used in about 80,000 patients in the U.S.

____

Online:

www.bmj.com.tamiflu/

Read More..

Probe shows federal power to access email

WASHINGTON (AP) — Your emails are not nearly as private as you think.

The downfall of CIA Director David Petraeus demonstrates how easy it is for federal law enforcement agents to examine emails and computer records if they believe a crime was committed. With subpoenas and warrants, the FBI and other investigating agencies routinely gain access to electronic inboxes and information about email accounts offered by Google, Yahoo and other Internet providers.

"The government can't just wander through your emails just because they'd like to know what you're thinking or doing," said Stewart Baker, a former assistant secretary at the Department of Homeland Security and now in private law practice. "But if the government is investigating a crime, it has a lot of authority to review people's emails."

Under the 1986 Electronic Communications Privacy Act, federal authorities need only a subpoena approved by a federal prosecutor — not a judge — to obtain electronic messages that are six months old or older. To get more recent communications, a warrant from a judge is required. This is a higher standard that requires proof of probable cause that a crime is being committed.

Public interest groups are pressing Congress for the law to be updated because it was written a quarter-century ago when most emails were deleted after a few months because the cost of storing them indefinitely was prohibitive. Now, "cloud computing" services provide huge amounts of inexpensive storage capacity. Other technological advances, such as mobile phones, have dramatically increased the amount of communications that are kept in electronic warehouses and can be reviewed by law enforcement authorities carrying a subpoena.

"Technology has evolved in a way that makes the content of more communications available to law enforcement without judicial authorization, and at a very low level of suspicion," said Greg Nojeim, a senior counsel at the Center for Democracy & Technology.

The chairman of the Senate Judiciary Committee, Patrick Leahy, has proposed changing the law to require a warrant for all Internet communications regardless of their age. But law enforcement officials have resisted because they said it would undercut their ability to catch criminals.

A subpoena is usually sufficient to require Internet companies to reveal names and any other information that they have that would identify the owner of a particular email account. Google, which operates the widely used Gmail service, complied with more than 90 percent of the nearly 12,300 requests it received in 2011 from the U.S. government for data about its users, according to figures from the company.

Even if a Gmail account is created with a fictitious name, there are other ways to track down the user. Logs of when messages are sent reveal the Internet address the user used to log onto the account. Matching times and dates with locations allow investigators to piece together the chain.

A Gmail account figured prominently in the FBI investigation that led to Petraeus' stunning resignation last week as the nation's spy chief. Petraeus, a retired Army general, stepped down after he confessed to an extramarital affair with Paula Broadwell, an Army Reserve officer and his biographer.

The inquiry began earlier this year after Jill Kelley, a Florida woman who was friends with Petraeus and his wife, Holly, began receiving harassing emails. Kelley is a Tampa socialite. That is where the military's Central Command and Special Operations Command are located.

Petraeus served as commander at Central Command from 2008 to 2010.

FBI agents eventually determined that the email trail led to Broadwell, according to two federal law enforcement officials, who spoke on condition of anonymity because the sources were not authorized to speak about the matter on the record. As they looked further, the FBI agents came across a private Gmail account that used an alias name. On further investigation, the account turned out to be Petraeus's.

The contents of several of the exchanges between Petraeus and Broadwell suggested they were having an affair, according to the officials. Investigators determined that no security breach had occurred, but continued their investigation into whether Petraeus had any role in the harassing emails that Broadwell had sent to Kelley, which was a criminal investigation.

Petraeus and Broadwell apparently used a trick, known to terrorists and teen-agers alike, to conceal their email traffic.

One of the law enforcement officials said they did not transmit all of their communications as emails from one's inbox to the other's inbox. Rather, they composed some emails in a Gmail account and instead of transmitting them, left them in a draft folder or in an electronic "dropbox." Then the other person could log onto the same account and read the draft emails there. This avoids creating an email trail which is easier to trace. It's a technique that al-Qaida terrorists began using several years ago and teen-agers in many countries have since adopted.

___

Associated Press writer Pete Yost contributed to this report.

Read More..

Panetta: Admin deciding on post-2014 troop levels

ABOARD A U.S. MILITARY AIRCRAFT OVER THE PACIFIC (AP) — Defense Secretary Leon Panetta said Monday the Obama administration is nearing a decision in the next few weeks on how many U.S. troops would remain in Afghanistan — and for what purposes — after the U.S.-led combat mission ends in 2014.

Panetta told reporters aboard his plane en route from Hawaii to Australia that Gen. John Allen, the top U.S. commander in Afghanistan, has developed several options on a post-2014 presence.

Panetta also was asked about his future at the Pentagon. While he declined to reveal his plans, he suggested he still had work to do on the job he took in July 2011.

"It's no secret that at some point I'd like to get back to California," he said. Panetta is from Monterey, Calif.

He added that there are a number of important defense issues awaiting resolution, including a budget impasse and the future of U.S. involvement in Afghanistan — suggesting that he would not leave immediately.

"Right now, my goal is to basically meet my responsibilities with regard to dealing with those issues," Panetta said.

Pressed to say whether he would rule out staying for all four years of a second Obama term, he replied, "Who the hell knows?"

Panetta said the Pentagon is reviewing those options with the White House. He would not reveal what troop levels are being considered, but it is believed that at least several thousand could be needed for several years beyond 2014.

"My hope is that we'll be able to complete this process in the next few weeks," Panetta said.

The decision will depend in part of the Afghan government's willingness to permit a post-2014 U.S. military presence and to provide legal guarantees for those troops that are acceptable to Washington.

Once that decision is made, U.S. officials have said they will set a timetable for reducing troop levels between now and the end of 2014. There now are about 67,000 U.S. troops in Afghanistan, and their mission is evolving from combat to advising, assisting and training Afghan forces.

A post-2014 U.S. military presence also would be expected to include hunting and killing extremists, including members of al-Qaida in Afghanistan.

Asked about David Petraeus's resignation as CIA director over revelations that he had an affair with his biographer, Panetta said he saw it as a "very sad situation to have him end his career like that." Panetta was CIA director before Petraeus.

"I think he took the right step" by resigning, Panetta added.

Panetta was beginning a weeklong trip to Asia to meet with his counterparts in Australia, Thailand and Cambodia. He said this was an important expression of the Obama administration's commitment to deepening ties in the region and developing more security partnerships.

For decades American administrations have fought the perception among Asians that Washington paid too little attention to their security interests. This view was reinforced during the years of U.S. focus on Iraq, and it persists even as the war in Afghanistan winds down.

The Obama administration has made much of its "pivot" to the Asia-Pacific, which has entailed more high-level diplomatic and security engagements and an attempt to expand cooperation with Australia and others in the region. But it is not fundamentally different from what the administration of President George W. Bush was pursuing even as it got mired in Iraq and saw stalemate in Afghanistan.

In June 2007, then-Defense Secretary Robert Gates argued at a security conference in Singapore that the U.S. was increasingly focused on Asia.

"Far from neglecting Asia, the U.S. is more engaged than ever before," he said. "We have been extraordinarily busy in recent years as we reshape and strengthen our security ties based on shared interests. Some are bilateral relationships that have been formed, renewed, or modernized - each with varying types and degrees of cooperation."

Among the issues dogging Panetta and the Pentagon is the controversy over the U.S. response to an attack on U.S. diplomatic facilities in Benghazi, Libya, two months ago.

Panetta said the Pentagon and the State Department are assessing what additional or improved arrangements might be necessary to secure U.S. diplomatic outposts in the Middle East. He was not specific.

As for the Benghazi attack, Panetta said it was "largely over" by the time the Pentagon was able to move forces close enough to Libya to respond.

Asked about the prospect of Congress and the administration settling for a short-term fix to the budget deficit crisis, rather than agreeing on measures to end the threat of further large defense spending cuts, Panetta said, "That's the worst thing that could happen."

He added: "That's the last damn thing I need right now," because it would perpetuate uncertainty about future defense spending and defense priorities.

Read More..